(Senior) Scientist, Translational Biology

About the role

FL106 develops novel drug delivery modalities. Bench translational biology role focuses on flow cytometry, primary cell isolation/sorting, microscopy/imaging, siRNA and mouse in vitro/in vivo studies. PhD plus 3–6+ years relevant experience, industry preferred. Cold-active dissociation of rare sensitive cells, intravital/super-resolution/high-content imaging, qPCR, Western blot, ELISA and RNA-seq are preferred. Cambridge, MA. Salary $126,000–$165,000.

Requirements

• Ph.D. in Molecular Biology, Cell Biology, or related field with 3–6+ years relevant experience; industry preferred.
• Strong flow cytometry, FACS, panel design, troubleshooting and data analysis.
• Hands-on primary cell isolation from mouse tissue, tissue dissociation, MACS and rare/fragile cell populations.
• Microscopy and image analysis software.
• siRNA design, delivery and functional validation.

What you'll do

• Design and execute complex preclinical in vitro/in vivo experiments.
• Lead multiparameter flow cytometry panel design and analysis.
• Isolate and sort primary cells while preserving viability and gene-expression signatures.
• Perform microscopy for cell/tissue phenotyping and target engagement.
• Support mouse disease models, dosing, tissue collection and phenotypic analysis.
• Develop siRNA target-validation approaches; mentor junior scientists and document results.

Where this was posted

• job-boards.greenhouse.io

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